Observe Carefully (three)pentobarbital will reduce the level or outcome of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Sturdy or average CYP3A4 inducers may perhaps boost rate of diazepam elimination; consequently, efficacy of diazepam may very well be lowered.pentobarbital will lessen the leve